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Priyanka Gehlot

Prime Minister Research Fellow (PMRF)

About

I am currently pursing PhD in Environmental Microbiology from Environmental Biotechnology Laboratory (EBL), Centre for Rural Development and Technology, IIT DELHI. I have been awarded Prime Minister Research Fellowship for pursing my PhD research. I have also been awarded University Gold Medal and was provisionally selected for DST-INSPIRE Fellow. I have qualified CSIR-JRF, GATE, DBT-JRF and ICAR-ASRB NET. In my initial educational period, I had worked in Bio-hydrometallurgy, Biofuels, Bio-processing, Bio- catalysis, Fermentation Technology and molecular biology. Currently at EBL, my area of expertise is Microbiology, Molecular Biology, Antibiotic Resistance, Environmental Biotechnology, Enzymology, β-lactamase resistance and Bioinformatics. My PhD work mainly focus on β-lactamase mediated β-lactam antibiotic resistance phenomena from various environmental samples across the Delhi-NCR region.

Basic Information
Email:
priyankagehlot1811@gmail.com , rdz198397@rdat.iitd.ac.in
Phone:
9602781984
Address:
Indian Institude of Technology Delhi, Hauz Khas, New Delhi, 110016
Achievements and Awards
  • Awarded University Gold Medal for Integrated M. Sc. Microbiology at 5th Annual Convocation, Central University of Rajasthan, Ajmer, Rajasthan held on 2nd November, 2018.
  • Awarded with DST INSPIRE FELLOWSHIP provisional offer letter on 20th December 2018.
  • Qualified GATE 2019.
  • Qualified ICAR-ASRB NET 2018.
  • Qualified and Awarded CSIR-JRF Examination in December 2018.
  • Qualified DBT-JRF 2019, Category B.
  • Awarded Prime Minister Research Fellowship through the Lateral Entry in December 2020.
  • Awarded Best AMI Poster for the poster entitle, “Polyphasic approach to track down the diversity of TEM β-Lactamase mutants from the environmental samples and their interaction with β-lactam and β-lactamase inhibitors” by the Association of Microbiologist’s India in the 63rd Annual International Conference of Association of Microbiologists of India (AMI) scheduled on 2 nd to 4th February 2023.
  • Received the Commendable performance award in the Annual Review held in December 2022.
Publications
  • Gehlot, Priyanka, and P. Hariprasad. "Computational and data mining studies to understand the distribution and dynamics of Temoneria (TEM) β-lactamase and their interaction with β-lactam and β-lactamase inhibitors." Environmental Pollution 314 (2022): 120289.
  • Raguraman, V., Chauhan, L.,Gehlot, P. , Kongkham, B., & Hariprasad, P. (2023). Computational insights into the role of structurally diverse plant secondary metabolites as inhibitors against Imidazole Glycerol Phosphate Dehydratase of Mycobacterium tuberculosis. Journal of Biomolecular Structure and Dynamics, 1-13.
  • Hittanahallikoppal Gajendramurthy Gowtham,Gehlot, Priyanka , and P. Hariprasad. "Untangling the Structure and Function of Rumen Microbes in Relation to Ruminant Health and Exploring Their Biotechnological Applications." In Animal Manure, pp. 61-106. Springer, Cham, 2022
  • Puttaswamy, Hariprasad, Hittanahallikoppal Gajendramurthy Gowtham, et al., Priyanka Gehlot, Leena Chauhan. "In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesis." Scientific reports 10, no. 1 (2020): 1-24.
  • Agarwal, Avantika, Kunwar Paritosh, Pragati Dangayach, Priyanka Gehlot, Nidhi Pareek, and Vivekanand Vivekanand. "Hydrothermal, acidic, and alkaline pretreatment of waste flower-mix for enhanced biogas production: a comparative assessment." Biomass Conversion and Biorefinery (2021): 1-9.
  • Gehlot, Priyanka, Nidhi Pareek, and V. Vivekanand. "Development of Biofertilizers and Microbial Consortium an Approach to Sustainable Agriculture Practices." In Plant, Soil and Microbes in Tropical Ecosystems, pp. 315-348. Springer, Singapore, 2021.
  • Gehlot, Priyanka, Manish Kumar, and Nidhi Pareek. "Production and purification of glutaminase free L-asparaginase from Lysinibacillus fusiformis and its appraisal in acrylamide mitigation of starchy foods." Materials Today: Proceedings (2022).
  • Gehlot, Priyanka, Vivekanand Vivekanand, and Nidhi Pareek. "Cyanobacterial and microalgal bioremediation: an efficient and eco-friendly approach toward industrial wastewater treatment and value-addition." In Microbial Biodegradation and Bioremediation, pp. 343-362. Elsevier, 2022.
Work Experience
  • Research project on "Bioleaching of Cu2+ ions from Electronic waste: PCB’s of waste mobile phone" from Central University of Rajasthan (Jan - May 2016).
  • Internship on "Pretreatment and Enhanced Biogas Production from Flower Waste" from MNIT Jaipur (June 2017).
  • Research project on "Production and Purification of Bacterial L-Asparaginase" during from Central University of Rajasthan (Jan - May 2018).
  • Worked as JRF on “Development of protocols for the production of value added biodegradable polymers from methane and CO2” funded by GAIL in DBBE, IIT Delhi (April-May 2019).
Education

On going

PhD
Environmental Biotechnology

Indian Institude of Technology

Polyphasic approach to understand the distribution and dynamics of TEM β-Lactamase in natural bacterial population.

2013 - 2018

Integrated M.Sc.
Microbiology

Central University of Rajasthan

Achieved 1st position with 5.5/6.0 CGPA.

2012 - 2013

12th Class
Science and Biology (CBSE)

ST. Mary’s Convent Sr. Sec. School Ajmer

Percentage : 86%.

2010 - 2011

10th Class
CBSE

ST. Mary’s Convent Sr. Sec. School Ajmer

CGPA : 9.0

PhD Work

Advancements in pharmaceuticals fields leads to the significant development of antibiotics which had saved many lives and will be continue to used as therapy for the various infectious diseases. The demand for antibiotics is increasing continuously with the increasing population. The total antibiotics consumption rate has been increasing continuously across the globe. In 1929, first β-lactam antibiotics i.e. Penicillin G (benzylpenicillin) was discovered and the clinical success of this promote the search and development of its other derivatives. The most commonly used antibiotic is β-lactam group which contain highly reactive β-lactam ring which renders the bacterial cell wall synthesis by inhibiting the function of transpeptidase (PBPs) enzymes.

Unfortunately, due to the continuous and non-scientific usage of antibiotics, in health, personal care and agriculture sector, the antibiotic load is increasing gradually in environment and hence, the bacterial communities are developing the antibiotic resistances. According to the Darwin Theory of “survival of the fittest” the organism which adopt better to selection pressure will proliferate better. Accordingly, bacteria are most versatile and through SOS response they can change their genetic makeup through mutations. By incorporating favorable mutations, they can survive in changing environment. Against the antibiotic selection pressure, the most noticed changes reported in bacteria are, overexpression of efflux pumps, production of β-lactamase enzymes and biofilm formations.

The most common mechanism developed by bacterial communities is production of β-lactamase enzymes to degrade the beta antibiotics with β-lactam moiety. β-lactamase are the hydrolytic enzymes which are further grouped into four classes such as class A, B, C and D based on the active site resides involved in acylation and deacylation catalytic reactions, substrate and inhibitors profile. The most commonly used and commercialized β-lactamase inhibitors were developed Clavulanic acid, sulbactam, and tazobactam. Recent report also evidenced the development of resistance against β-lactamase inhibitors which raises the concern of using these inhibitors.

Due to this continuous battle of antibiotics and antibiotic resistance, we had decided to track the favorable mutations in bacteria leading to the antibiotic resistance to improve the management strategies.

Contact Me

Address

Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016

Phone

9602781984

Email

priyankagehlot1811@gmail.com , rdz198397@rdat.iitd.ac.in